Beat the egg with 1 Tbsp. water and a dash of salt.
Add the garlic and onion powder, Cajun BBQ salt, and smoked paprika to 1 cup of Panko bread crumbs.
Soak the frog legs in the egg bath for about 10 minutes, turning half way so each side gets plenty of egg.
Dredge the legs in the seasoned Panko thoroughly on both sides. You may need to use your fingers to press the seasoned Panko onto the legs.
Dip into the egg bath again and repeat the Panko dredge.
Let the breaded frog legs rest for about 10 minutes before frying.
In a heavy bottomed skillet, get 1 1/2 inches of vegetable oil very hot. Test the temperature of the oil by flicking a drop of water into the pan. If it sizzles, you are ready to fry.
Gently place the legs into the hot oil and cook for 4-5 minutes. Turn the legs over and finish cooking for another 4-5 minutes until they are a rich, golden brown and begin to float in the oil.